Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation

Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.

Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de novo lipogenesis (DNL) and protects against diet-induced hepatic steatosis and adiposity. To understand the mechanism by which hepatic MUFA production influences adipose t...

Hepatic Fatty Acid Oxidation and Ketogenesis in Young Pigs

A primary limitation to efficient pork production is morbidity and mortality during the perinatal period. Because pigs are born with low energy reserves, their survival hinges on timely consumption of milk. In contrast to carbohydrate-based fetal metabolism, the transition to a milk-based diet necessitates rapid biochemical adaptations to accommodate the oxidation of fatty acids which comprise ...

Regulation of hepatic fatty acid oxidation and ketogenesis.

Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health

Recent studies have demonstrated that repeated short-term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity. Despite this, the molecular physiological mechanisms by which fasting is protective against metabolic disease are largely unknown. Here, we show that, metabolic control, particularly systemic and liver lipid metabolism, is aberrantly re...

Fatty Acid oxidation defects.

Fatty acid oxidation defects (FAODs) are a group of inborn errors of metabolism that carry a risk for morbidity and mortality. Successful management of these conditions involves early diagnosis, proper management of clinical situations that predisposes to metabolic crisis as well as adequate treatment of a metabolic crisis. The advent of tandem mass spectrometry based newborn screening has redu...